By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer causing agents of business origins.
The e-book discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and comparable aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and comparable compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The ebook additional tackles the structure-activity relationships, metabolism, and environmental importance if fatty acids, detergents, and different surfactants with oncogenic strength. The textual content then appears to be like into the impact of chemical reactivity, molecular geometry, and metabolism on carcinogenic task.
Chemists, geneticists, and people fascinated about melanoma learn will locate the e-book useful.
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Additional resources for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
At doses that were not maternally toxic, no teratogenic effects were noted. Trichloroethylene and tetrachloroethylene were tested in Sprague-Dawley rats and Swiss Webster mice by Schwetz et al. (193). Exposure of the rodents to 300 ppm of either compound for 7 h/day during the period of organogenesis caused no maternal toxicity, fetotoxicity, or teratogenic effects. This study alone is probably inadequate to assess fully the teratogenic potential of trichloro- and tetrachloroethylene. Soviet researchers have extensively studied the health effects of 2chloro-1,3-butadiene (chloroprene).
No tumors were seen in the liver and kidney. 1 Halogenated Linear Alkanes and Alkenes I 43 high incidences of testicular and mammary tumors in the low-dose group the authors (245) did not attribute tumor induction to CHC13 treatment because of the long duration of the study and the lack of dose dependence. Heywood et al. (245) concluded that exposure of beagle dogs to CHC13 had no effect on the incidence of tumors in beagle dogs. 3 Halomethanes other than carbon tetrachloride and chloroform. In addition to carbon tetrachloride and chloroform, eleven other halomethanes have been tested for carcinogenicity, and the results of these studies are summarized in Table XIV.
0 5 . 1 Halogenated Linear Alkanes and Alkenes I 37 marginal activity. With the exception of tert-buty\ iodide (tested at a very low dose) and iodoethane, all iodoalkanes tested are active. The negative finding of iodoethane is surprising in view of the fact that its lower and higher homologs are all active. Among the butyl halides tested, tert- and sec-butyl chlorides are both active, whereas their n-isomer is not. This is consistent with the expected higher alkylating activity (via an SN1 mechanism) of tertiary and secondary than of primary alkyl halides.