By Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain
Written for researchers, lecturers and execs, those papers signify an imperative reference resource at the most up-to-date developments and findings within the box of proteins, amino acids and peptides. content material: Preface; Amino acid and petide bioconjugates; Self-assembling peptide fabrics; steel complexes of amino acids and peptides; version structures for folding and teriary contacts in peptides: A standpoint from the actual sciences; Protein nanotubes, channels and cages; Prescriptive peptide layout; focusing on alpha-helix established protein interactions - nuclear receptors as a case learn summary: Written for researchers, lecturers and pros, those papers characterize an fundamental reference resource at the newest developments and findings within the box of proteins, amino acids and peptides
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5 E. M. Sletten and C. R. Bertozzi, Angew Chem Int Ed, 2009, 48, 6974. 6 M. Boyce and C. R. Bertozzi, Nat. Methods, 2011, 8, 638. 7 P. V. Chang, J. A. Prescher, E. M. Sletten, J. M. Baskin, I. A. Miller, N. J. Agard, A. Lo and C. R. Bertozzi, Proc Natl Acad Sci U S A, 2010, 107, 1821. 8 K. E. Sapsford, K. M. Tyner, B. J. Dair, J. R. Deschamps and I. L. Medintz, Anal Chem, 2011, 83, 4453. 9 S. Aggarwal, M. W. Ndinguri, R. Solipuram, N. Wakamatsu, R. P. Hammer, D. Ingram and W. Hansel, Int J Cancer, 2011, 129, 1611.
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77 Another review by K. A. 217 R. Y. Tsien et al. employed ﬂuorescently labelled, polycationic cell-penetrating peptide coupled via a cleavable linker to a neutralizing peptide. Upon exposure to proteases characteristic of tumour tissue, the linker was cleaved, dissociating the inhibitory peptide and allowing the CPP to bind to and enter tumour cells. Surgery guided by this method resulted in fewer residual cancer cells, resulting in improved precision of tumour resection. Q. T. Nguyen and co-workers using phage display techniques identiﬁed an oligopeptide, which binds selectively to peripheral nerves.